Monolaurin & Laruic Acid, a review.
A Review of Monolaurin and Lauric Acid – Natural Virucidal and Bactericidal Agents Shari Lieberman, Ph.D., C.N.S., F.A.C.N., Mary G. Enig, Ph.D., C.N.S., M.A.C.N., and Harry G. Preuss, M.D., C.N.S., M.A.C.N. ALTERNATIVE & COMPLEMENTARY THERAPIES—DECEMBER 2006 (310- 314)
Monolaurin has “Generally Recognized As Safe (GRAS)” status and is considered to be nontoxic. It is effective against many microorganisms and can be taken on a daily basis, given that evidence suggests it does not create antiviral or antibacterial resistance. The general recommended adult dose of monolaurin is 1–3 g. Higher amounts can be used to achieve desired results if necessary. It is safe for children (ages 3–10) with the recommended dose being smaller—30 mg, one to three times per day. Monolaurin is available as minipellets that should be swallowed and not chewed. Coconut oil, coconut cream and grated coconut are excellent sources of lauric acid and the other medium-chain fatty acids as well. Coconut oil provides mostly medium-chain triglycerides that are rapidly absorbed and transported to the mitochondria where they are utilized for fuel and may be less likely to be stored as body fat. Coconut oil does not have a deleterious effect on cholesterol or other blood lipids.
In fact, it may raise high-density lipoprotein cholesterol. Coconut oil is rich in “good” saturated fatty acids that conserve the elongated omega-3 fatty acid. Animal studies have shown that some omega-3 fatty acids can be formed as a result of ingestion of coconut oil. Coconut oil does not contain trans fatty acids that have deleterious effects on blood lipids and insulin binding. Both monolaurin and coconut oil are excellent choices for combating a host of microorganisms—both therapeutically and preventively. More human studies are needed to elucidate the best therapeutic dose of monolaurin and coconut for addressing specific microorganisms and conditions. It is also important to quantify how much monolaurin is metabolized from a specific quantity of coconut oil. Finally, it is equally important to compare large doses of coconut oil to specific doses of monolaurin for their antimicrobial action as was done in the HIV study population. Dietary supplements such as monolaurin may be unavailable to some populations while coconut oil may be a less-costly alternative. Coconut oil in health and disease: its and monolaurin’s potential as cure for HIV/AIDS By Dr. Conrado S. Dayrit The coconut is called the tree of life for it has been providing us, humans, food and drink, materials for housing, fuel and many industrial uses. And its medicinal uses are many and varied. The latest medical potential of products of the coconut first identified by Jon Kabara and others in the 70s, is the anti- bacterial, anti-viral and anti-fungal activity of its medium chain fatty acids, particularly lauric acid (C12:0) in its monoglyceride form (monolaurin or ML).The first clinical trial ever of ML was on 15 HIV-infected patients reporting regularly at the San Lazaro Hospital, Manila who, never having received any anti-HIV medication, were randomly assigned to 3 treatment groups: 7.2 g ML, 2.4 g ML and 50 ML of coconut oil daily for 6 months.
The San Lazaro Hospital Team was led by Eric Tayag. Viral, CD4 and CD8 counts, complete blood counts, blood lipids and tests for liver and kidney functions were done at the beginning of the study and after 3 and 6 months of treatment. In one patient, the viral load was too low to count. By the 3rd month, 7 of the patients (50%) showed reduced viral load and by the 6th month 8 patients (2 receiving 7.2h ML, 4 receiving 2.4 g ML and 3 receiving, coconut oil had a lowered viral count. The CD4/CD8 counts showed a favorable increase in 5 patients. There were no serious side effects observed. Three patients developed AIDS on 3rd month of therapy when their CD4 count dropped below 200. One of these three, who was in the coconut oil group died 2 weeks after the study. The two other AIDS patients were in the 2.4 g ML group; one recovered fully on the 6th month and the other showed a rapid return towards normal CD4 and CD8 counts. Effects of Essential Oils and Monolaurin on Staphylococcus aureus: in vitro and in vivo Studies Harry G. Preuss, Bobby Echard The antimicrobial properties of volatile aromatic oils and medium chain fatty acids derived from edible plants have been recognized since antiquity. To give examples, Origanum oil, used as a food-flavoring agent, possesses a broad spectrum of antimicrobial activity due, at least in part, to its high content of phenolic derivatives such as carvacrol and thymol. Similarly, lauric acid, present in heavy concentrations in coconuts, forms monolaurin in the body that can inhibit the growth of pathogenic microbes. Using Staphylococcus aureus in broth cultures and a micro dilution method, comparative efficacy of Origanum oil, and a constituent carvacrol, other essential oils, and monolaurin were examined. Origanum oil was the most potent of the essential oils tested and proved bactericidal in culture to two strains of Staphylococcus aureus at 0.25 mg/ml. In vitro, monolaurin’s effects mirrored Origanum oil. The combination of both was bactericidal at the 0.125 mg/ml concentration of each. In two separate in vivo experiments, injected Staphylococcus aureus killed all 14 untreated mice within a one-week period. In treated mice, over one third survived for thirty days when given oral Origanum oil daily for 30 days (6/14). Fifty percent of the mice survived for 30 days when receiving daily vancomycin (7/14) and monolaurin (4/8). Over sixty per cent of mice survived when receiving a daily combination of Origanum oil and monolaurin (5/8). Origanum oil and/or monolaurin may prove to be useful antimicrobial agents for prevention and therapy of Staphylococcus aureus infections.